Diart One Clinical Evidences

DIART ONE
CLINICAL EVIDENCES

DIART ONE Demonstrates Viscoelastic Properties Comparable to Healthy Synovial Fluid at Physiological Frequency (2.5 Hz)

The elastic modulus (G’)

is identical to that of synovial fluid of a healthy young person

The viscous modulus (G’)

is 6-7 times higher than the loss modulus of the synovial fluid, and, therefore, there is compensation for the shock-absorbing function of the synovial cartilage, which is damaged in patients with OA

DIART ONE Showed Tolerability and Safety in a Single Injection for 6 Months in Subjects with Knee OA Grades II to IV Kellgren and Lawrence Classification¹

DIART ONE showed:

Knee (KL grade)	1	2	3	4
Left %	7.3	36.4	16.4	7.3
Right %	7.3	32.7	27.3	1.8

References:

Nazar Vadzyuk Postmarketing, Prospective, Multicentre, Single-Arm Study of Subjects Who Receive an Injection of a Medical Device Based on Hyaluronic Acid: Clinical Study Report. World Science. 1(83). doi: 10.31435/rsglobal_ws/30032024/8127

40353025 20151050

39.75

25.02

19.37

15.67

60.58%

16.13

16.43

15.81

BASELINE 1 MONTH 2 MONTHS 3 MONTHS 4 MONTHS 5 MONTHS 6 MONTHS

Figure 2. Mean of the WOMAC index total score after replacement of the outliers with the dataset median

Clinically Significant Reduction in Knee Pain with Psychological Improvements Before and After Injection of HA in Knee OA in 12 Months Study²

DIART ONE showed:

References:

Vincenzo Rania, et al. (2024) Efficacy and Safety of Intraarticular Therapy with Cross-Linked Hyaluronic Acid in Patients with Knee Osteoarthritis. doi: 10.20944/preprints202411.2249.v1